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Pharmacotherapeutic Group: Proton Pump Inhibitors.
Pharmacology: Pharmacodynamics: Omeprazole markedly inhibits basal and stimulated gastric acid secretion. It has a unique mode of irreversibly blocking the so called proton pump of the parietal cells which is supposedly the terminal step in the acid secretory pathway.
Pharmacokinetics: Omeprazole is rapidly absorbed after release from enteric-coated formulations. Peak plasma concentration of Omeprazole occurs within 0.5 to 3.5 hours following oral administration. Plasma protein binding of it is about 95-96%. Omeprazole is eliminated rapidly and almost completely by metabolism. Three metabolites observed in plasma are sulfide and sulfone derivatives of Omeprazole and hydroxyomeprazole. These metabolites have very little or no antisecretory activity.
