Not to be applied over breast or mucous membranes. Discontinue use if breast tension, abdomen swelling, anxiety, irritability occurs. History of CVA (haemorrhage or blood clot); family medical history of breast cancer. Vascular disorders (ocular of the retina). Overwt, severe diabetes, high BP, endometriosis, kidney failure or hepatic disorders, epilepsy, asthma, lupus, pituitary tumour, porphyria, otospongiosis. Bedridden patient. Scheduled surgery. Periodic medical exam for breast nodule or cyst prior to, or during treatment. Kidney failure or hepatic disorders. Itching during previous pregnancy. Pregnancy & lactation.