Noxafil Dosage/Direction for Use

General: Noxafil Tablets may be taken without regard to food intake.
Important Administration Instructions for Noxafil Tablet and Noxafil Oral Suspension: The prescriber should follow the specific dosing instructions for each formulation. The tablet and oral suspension are not to be used interchangeably due to the differences in the dosing of each formulation.
Dose and Duration: See Table 1.

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Use in renal impairment: No dose adjustment is required for renal dysfunction and posaconazole is not significantly renally eliminated, an effect of severe renal insufficiency on the pharmacokinetics of posaconazole is not expected and no dose adjustment is recommended.
Use in hepatic impairment: There are limited pharmacokinetic data in patients with hepatic insufficiency; therefore, no recommendation for dose adjustment can be made. In the small number of subjects studied who had hepatic insufficiency, there was an increase in half-life with a decrease in hepatic function.
Use in Pediatrics: Safety and efficacy in adolescents and children below the age of 13 years have not been established.
Method of Administration: Non-Interchangeability between Noxafil Tablets and Noxafil Oral Suspension: Noxafil Tablets and Oral Suspension are not to be used interchangeably due to the differences in the dosing of each formulation. Therefore, follow the specific dosage recommendations for each of the formulations.
Noxafil Tablets are intended for oral administration only.
Noxafil Tablets should be swallowed whole, and not be divided, crushed, or chewed.