May cause allergic-type reactions including anaphylactic symptoms & life-threatening or less severe asthmatic episodes. Sulfite sensitivity more frequently in asthmatic than in non-asthmatic patient. Not to be used in patients w/ hypotension, diabetes, cardiac or thyroid disease. May occur occlusive vascular diseases (eg, atherosclerosis, arteriosclerosis, diabetic endarteritis, Buerger's disease) in lower than in upper extremity; gangrene in lower extremity when infusions were given in an ankle vein. May result to severe, prolonged HTN in patients receiving MAOIs or antidepressants of triptyline or imipramine types. Possible high BP w/ pressor agent overdose. Frequently check infusion site for free flow. Consider changing infusion site at intervals to allow effects of local vasoconstriction to subside if blanching occurs. Gradually reduce & avoid abrupt w/drawal of treatment. Avoid catheter tie-in technique if possible; contact w/ Fe salts, alkalis, or oxidizing agents. Pregnancy & lactation. Ped patients. Elderly ≥65 yr. Not to be administered into the leg veins of elderly patients.
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