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Pharmacology: Pharmacodynamics: Orphenadrine citrate is salt form of orphenadrine. It acts in the central nervous system at the brainstem. It has no direct effect of muscle relaxation. In animal it inhibited specifically to reticular formation (substantia reticularis). Orphenadrine does not have myoneural block activity and had no effect on crossed extensor reflex. It is classified as anticholinergic skeletal muscle relaxant. It may involve with analgesic activity and/or muscle relaxation activity for skeletal muscle. Orphenadrine is o-methyl analog of diphenhydramine which is antihistamine without sedative effect. On the contrary, it stimulated central nervous system mildly.
Pharmacokinetics: Orphenadrine is readily absorbed from the gastrointestinal tract and is almost completely metabolized to at least eight metabolites. Orphenadrine and its metabolites are excreted from the body in the urine, with a half-life of 14 hours.
