IM/IV Adult Complicated UTI & serious systemic infections 4-6 mg/kg daily (1.3-2 mg/kg every 8 hr or 2-3 mg/kg every 12 hr).
Life-threatening infections Up to 7.5 mg/kg daily administered in 3 equal doses every 8 hr. Reduce to ≤4-6 mg/kg daily as clinically indicated, usually w/in 48 hr.
Childn 6-7.5 mg/kg daily (2-2.5 mg/kg every 8 hr).
Infant & neonate >1 wk 7.5-9 mg/kg daily (2.5-3 mg/kg every 8 hr).
Premature or full-term neonate <1 wk 6 mg/kg daily (3 mg/kg every 12 hr). Treatment duration: 7-14 days.
Renal impairment Adjusted total daily dose: 1 dose at 24-hr intervals, or as 2 or 3 equally divided doses at 12- or 8-hr intervals, respectively. Max: 3.25 mg/kg each individual dose.
Adults undergoing hemodialysis 2 mg/kg at the end of each dialysis period.
Childn undergoing hemodialysis 2-2.5 mg/kg, depending on severity of infection.
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