Adult 25 mg once daily. Severe renal impairment (CrCl ≥15 to <30 mL/min) or w/ ESRD (CrCl <15 mL/min) or requiring hemodialysis 6.25 mg once daily. Moderate renal impairment (CrCl ≥30 to <60 mL/min) 12.5 mg once daily.
Patients w/ liver disease. Discontinue if pancreatitis (promptly) & serious hypersensitivity reaction is suspected. History of angioedema w/ another dipeptidyl peptidase-4 (DPP) inhibitor.
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