Adult Mantle cell lymphoma &/or relapsed multiple myeloma Usual dose: 1.3 mg/m
2 twice wkly for 2 wk (days 1, 4, 8, & 11) followed by 10-day rest period (days 12-21). Maintenance dose: For extended therapy of >8 cycles, may be administered on standard or maintenance schedule of once wkly (days 1, 8, 15, & 22), followed by 13-day rest period (days 23-35). At least 72 hr should elapse between consecutive doses.
Grade 3 non-hematological or grade 4 hematological toxicities excluding neuropathy May be initiated at 25% reduced dose (1.3 mg/m
2/dose reduced to 1 mg/m
2/dose; 1 mg/m
2/dose to 0.7 mg/m
2/dose) once symptoms of toxicity have resolved.
Previously untreated multiple myeloma In combination w/ melphalan 9 mg/m
2 & prednisone 60 mg/m
2 in days 1-4 for nine 6-wk treatment cycles: Bortezomib 1.3 mg/m
2/dose twice wkly in cycles 1-4 (days 1, 4, 8, 11, 22, 25, 29, 32) & once wkly in cycles 5-9 (days 1, 8, 22, 29). At least 72 hr should elapse between consecutive doses of bortezomib.
Induction therapy prior to stem-cell transplantation In combination w/ dexamethasone: 1.3 mg/mL by IV inj twice wkly for 2 wk (days 1, 4, 8, & 11) followed by 10-day rest period (days 12-21). Dexamethasone 40 mg was administered orally in cycles 1 & 2 on days 1-4 & 9-12, & in cycles 3 & 4 on days 1-4.