Hypersensitivity. Hemorrhagic tendencies or blood dyscrasias; recent or contemplated CNS or eye surgery/traumatic surgery resulting in large, open surfaces; GI & resp tract or GUT bleeding; aneurysm; pericarditis & pericarditis effusion; bacterial endocarditis; spinal puncture; lumbar block anesth. Women of childbearing potential. Pregnancy.
Risk of hemorrhage; necrosis & gangrene of skin & other tissues. Protein C & S deficiencies. Concomitant administration w/ NSAIDs eg, aspirin. Birth malformations in childn born to mothers receiving treatment during pregnancy. Childn <18 yr. Elderly (lower initiation & maintenance dose recommended).
Hypersensitivity/allergic reactions. Fatal or non fatal hemorrhage from any organ/tissue, paralysis, paresthesia, headache, chest, abdomen, joint, muscle or other pain, dizziness, shortness of breath, difficult breathing/swallowing, unexplained swelling & shock, weakness, hypotension; necrosis of skin & other tissues.
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