Monet Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Thai FDA Category Presentation/Packing

Concise Prescribing Info

Contents

Manidipine HCl

Indications/Uses

Mild to moderate essential HTN & HTN w/ renal impairment.

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Dosage/Direction for Use

Adult 10-20 mg once daily. Starting dose: 10 mg daily. May be increased to 20 mg daily if antihypertensive effect is inadequate after 2-4 wk. Elderly 10 mg daily. Patients w/ mild hepatic dysfunction Max: 10 mg daily.

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Overdosage

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Administration

Should be taken with food: Take after breakfast.

Contraindications

Hypersensitivity to manidipine & any dihydropyridine agents. MI in the 1st 4 wk; unstable angina pectoris, untreated heart failure, galactose intolerance, glucose-galactose malabsorption, Lapp lactase deficiency. Concomitant use w/ CYP3A4 inhibitors & inducers. Moderate to severe hepatic dysfunction. Severe renal dysfunction (CrCl <10 mL/min). Pregnancy. Childn.

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Special Precautions

Possible increased coronary risk in coronary stable patients. Patients w/ isolated-right-sided heart failure, left ventricular dysfunction, left ventricle obstruction of the outflow channel, sick sinus syndrome. Mild hepatic impairment. Lactation. Elderly.

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Use In Pregnancy & Lactation

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Adverse Reactions

Facial hot flushes, feeling warmth, palpitation, peripheral edema, tachycardia, hypotension, HTN, chest pain; pruritus, rash, eczema, erythema; nausea, vomiting, anorexia, stomach discomfort, heartburn, enlarged feeling of abdomen, diarrhea, constipation, xerostomia, gastralgia, abdominal pain; leukopenia, prolonged bleeding time; headache, dizziness, vertigo, numbness, paresthesia, weakness, Parkinsonian symptoms; irritability, somnolence; elevation of GOT, GPT, γ-GPT, LDH, alkaline phosphatase, BUN, serum creatinine.

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Drug Interactions

May intensify the action of other antihypertensive drugs. Action may be intensified w/ cimetidine. May have additive effect on AV node conduction, & increased risk of bradycardia & advanced or complete heart block w/ digoxin. Concomitant use w/ amiodarone. Increased conc & toxicity w/ dalfopristin/quinupristin.

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Storage

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Description

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Action

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MIMS Class

Calcium Antagonists

ATC Classification

C08CA11 - manidipine ; Belongs to the class of dihydropyridine derivative selective calcium-channel blockers with mainly vascular effects. Used in the treatment of cardiovascular diseases.

Thai FDA Category

Presentation/Packing

Form

Monet tab 20 mg

Packing/Price

10 × 10's

Monet

manidipine

Manufacturer:

Millimed

Distributor:

Prosp Pharma

Marketer:

Prosp Pharma