Mofacin

Moxifloxacin HCl

Bacterial infections caused by susceptible strains in adults ≥18 yr, resp tract infections, skin & soft tissue infections, complicated intra-abdominal infections including polymicrobial infections.

Adult 400 mg IV infusion for 60 min once daily. Acute exacerbation of chronic bronchitis 400 mg every 24 hr for 5 days. Acute sinusitis, uncomplicated skin & soft tissue infections 400 mg every 24 hr for 7 days. Community acquired pneumonia 400 mg every 24 hr for 7-14 days. Complicated skin & soft tissue infections 400 mg every 24 hr for 7-21 days. Complicated intra-abdominal infections 400 mg every 24 hr for 5-14 days.

Hypersensitivity to moxifloxacin or other quinolones. Pregnancy & lactation. Patients <18 yr.

Myasthenia gravis. Discontinue treatment if hypersensitivity & allergic reactions occurs; psychiatric reactions. Prolonged QT interval. Patients w/ known prolongation of QTc interval, uncorrected hypokalemia, receiving class IA (eg, quinidine, procainamide) or class III (eg, amiodarone, sotalol) antiarrhythmic agents. Concomitant use w/ drugs that prolong the QTc interval eg, cisapride, erythromycin, antipsychotics & TCAs; patients w/ ongoing proarrhythmic conditions eg, clinically significant bradycardia, acute myocardial ischemia; liver cirrhosis; women & elderly. Fulminant hepatitis; SJS or TEN. CNS disorders. Initiate adequate therapeutic measures in patients who develop serious diarrhea; drug-induced inhibition of peristalsis are contraindicated. Tendon inflammation & rupture may occur in elderly patients & those treated concurrently w/ corticosteroids. Not recommended for patients w/ complicated pelvic inflammatory disease & for treatment of MRSA infections. May cause false -ve results in Mycobacterium spp culture test. Sensory or sensorimotor polyneuropathy resulting in paraesthesias, hypoaesthesias, dysaesthesias or weakness. Psychotic patients or w/ history of psychiatric disease. Avoid monotherapy treatment in patients w/ pelvic inflammatory disease. May impair ability to drive or operate machinery.

Mycotic superinfections; headache, dizziness; QT prolongation in patients w/ hypokalemia; nausea, vomiting, GI & abdominal pains, diarrhea; increased transaminases; inj & infusion site reactions.

Quinolones

J01MA14 - moxifloxacin ; Belongs to the class of fluoroquinolones. Used in the systemic treatment of infections.

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