Monotherapy Initially 250 mg bid, increased to 500 mg bid after 2 wk. May be further increased by 250 mg bid every 2 wk depending upon clinical response. Max: 1,500 mg bid.
Adjunctive therapy Adult ≥18 yr & adolescent 12-17 yr weighing ≥50 kg Initially 1,000 mg/day & may be started on 1st day of treatment. May be increased up to 3,000 mg/day. Dose changes can be made in 1,000 mg/day increments or decrements every 2-4 wk.
Childn 4-11 yr & adolescents 12-17 yr weighing <50 kg Initially 10 mg/kg bid. May be increased up to 30 mg/kg bid. Dose changes should not exceed 10 mg/kg bid increments or decrements every 2-4 wk.
Childn & adolescents weighing from 50 kg Initially 500 mg bid. Max dose: 1,500 mg bid,
25 kg Initially 250 mg bid. Max dose: 750 mg bid.
Monotherapy or adjunctive therapy Adult & adolescent ≥50 kg w/ impaired renal function: ESRD patients undergoing dialysis 500-1,000 mg once daily. Loading dose: 750 mg on the 1st day w/ levetiracetam. Following dialysis, a 200-500 mg supplemental dose is recommended,
severe <30 mL/min/1.73 m2 250-500 mg bid,
moderate 30-49 mL/min/1.73 m2 250-750 mg bid,
mild CrCl 50-79 mL/min/1.73 m2 500-1,000 mg bid.
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