Discontinue if fever, throat pain, stomatitis, other signs & symptoms suggestive of infection occur; in the presence of jaundice; in patient entering manic phase. History of suicide-related events, suicide ideation; mania/hypomania; seizures. Bone marrow depression usually after 4-6 wk of treatment. Exacerbation of psychotic symptoms; intensified paranoid thoughts; switch to manic phase; akathisia/psychomotor restlessness. Avoid abrupt treatment cessation. Patients w/ epilepsy or organic brain syndrome; heart disease (eg, conduction disturbances, angina pectoris or recent MI); hypotension; micturition disturbances (eg, prostatic hyperplasia); acute narrow angle glaucoma & elevated IOP; DM. Galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Concomitant use w/ medications known to cause hyponatraemia; serotonergic active substances. May affect ability to drive & use machines. Hepatic & renal impairment. Not to be used during pregnancy. Not recommended during lactation. Increased risk of persistent pulmonary HTN in newborn. Not to be used in childn & adolescents <18 yr. Elderly.
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