Discontinue treatment if nephrotoxicity, manifested as decreased urine output, increased serum conc of BUN & creatinine, proteinuria, hematuria & casts in urine occurs. Closely monitor patients if transient nervous system effect, including circumoral or peripheral paresthesia or numbness, tingling or formication of extremities or tongue, dizziness, vertigo, giddiness, ataxia, blurred vision & slurred speech appear.
Clostridium difficile-associated diarrhea (CDAD). Manage moderate to severe colitis w/ fluid, electrolyte, protein supplementation & appropriate anti-infective therapy. Premed w/ bronchodilators to reduce development of bronchoconstriction in patients given by oral inhalation via nebulization. Avoid concurrent or sequential use w/ drugs having similar nephrotoxic effects & w/ neuromuscular blocking agents. Pregnancy. Temporarily discontinue during lactation.
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