Discontinue treatment if fever, rashes, blisters, skin peeling, stomatitis, pharyngitis, rhinitis, conjunctivitis, genital inflammation occur. History of hypersensitivity to penicillins; possible death in penicillin-allergic patients. Personal or familial predisposition to allergic symptoms eg, bronchial asthma, exanthema or urticaria. May cause vascular pain & phlebitis (due to IV administration in large dose). Possibility of developing
Clostridium difficile &
Klebsiella oxytoca. Patients who are poorly & parenterally nourished or in poor general condition. Observe patients for vit K deficiency symptoms; immediately after administration. Avoid alcohol intake during & at least 1 wk after treatment. False +ve in creatinine test using Yaffe's reaction; direct Coomb's reaction. Reduced potency when mixed w/ aminophylline or pyridoxal phosphate. Severe renal impairment. Pregnancy. Newborns & premature infants. Elderly (bleeding tendency due to vit K deficiency).
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