Meiact

Cefditoren pivoxil

Acute bacterial exacerbation of chronic bronchitis. Mild to moderate community-acquired pneumonia, pulmonary suppuration, pharyngitis, tonsillitis, acute maxillary sinusitis, otitis media, scarlet fever, pertussis. Superficial secondary infection in trauma. Uncomplicated skin & skin-structure infections eg, cellulitis, infected wounds, abscesses, folliculitis, impetigo & boils, furuncle, furunculosis, carbuncle, erysipelas, phlegmon, lymphangitis (lymphadenitis), suppurative perionychia (paronychia), infectious atheroma. Pyelonephritis, cystitis.

100 mg tab Adult 100 mg tid. Severe infections 200 mg tid. Lower UTI or switch therapy of UTI following clinical response w/ IV cephalosporins 400 mg once daily. 200 mg tab Recommended dose depends on severity of infection, basal condition & potential microorganisms involved. Adult & adolescent >12 yr Acute pharyngo-tonsillitis, acute maxillary sinusitis, uncomplicated skin & skin structure infections 200 mg every 12 hr for 10 days. Acute exacerbations of chronic bronchitis 200 mg every 12 hr for 5 days. Community-acquired pneumonia Mild cases: 200 mg every 12 hr for 14 days. Moderate cases: 400 mg every 12 hr for 14 days. Pyelonephritis, cystitis 400 mg once daily after meal. Moderate renal insufficiency (CrCl 30-50 mL/min) Max total daily dose: 200 mg every 12 hr. Severe renal insufficiency (CrCl <30 mL/min) 200 mg as a single dose once daily. Fine granules for oral soln Childn 9-18 mg/kg daily bid-tid after meals. Dose adjustment: Patient weighing >30 kg Administer adult dosage (as two 50 mg sachet or 100 mg tab) tid, >20-30 kg 80 mg tid (as one 30 mg sachet & 50 mg sachet), >16-20 kg 60 mg tid (as two 30 mg sachet), >10-16 kg 50 mg tid, >6-10 kg 30 mg tid.

Should be taken with food.

Hypersensitivity to cefditoren, cephem antibiotics & any other cephalosporin, casein (only for 200 mg tab). Previous immediate &/or severe hypersensitivity to penicillin or to any other type of β-lactam active substance. History of anaphylactic shock. Primary carnitine deficiency.

History of hypersensitivity to cefditoren, penicillins, cephalosporins or other β-lactam active substance. Carefully assess patients for risk of shock. Discontinue if severe &/or bloody diarrhoea occurs during treatment & institute appropriate therapy. Personal or familial predisposition to allergic symptoms eg, bronchial asthma, exanthema or urticaria. Patients w/ poor oral food intake or who are receiving parenteral alimentation, & patients in poor general health; malnourished; on controlled Na diet. Vit K deficiency may develop. Limit the duration of administration to the min period required for the treatment to prevent drug-resistant microorganisms. Antibiotic-associated diarrhoea, colitis & pseudomembranous colitis. History of GI disease particularly colitis. Patients receiving concurrent treatment w/ nephrotoxic substances (eg, aminoglycosides) or potent diuretics (eg, furosemide). May result in overgrowth of non-susceptible organisms eg, enterococci and Candida spp. Monitor prothrombin time in patients at risk of decreased prothrombin activity eg, patients w/ renal or hepatic insufficiency or being treated w/ anticoagulant therapy. Reduce total daily dosage in patients w/ acute or chronic moderate to severe renal insufficiency. Prolong administration interval in patients w/ impaired renal function. Minor or moderate influence on the ability to drive and use machines. Pregnancy. Not recommended during lactation. Low birth-wt infants, suckling infants, infants, newborns.

Diarrhoea. Headache; nausea, abdominal pain, dyspepsia; vag candidiasis. Exanthema; granulocytopenia, eosinophilia; increased AST, ALT & AI-P; increased BUN & serum creatinine, proteinuria; loose stools, stomach discomfort. SJS, TEN.

Decreased AUC & C_max w/ Mg- & Al hydroxide-containing antacids & IV famotidine. Increased AUC & C_max w/ probenecid. May induce false +ve in the direct Coomb's test. False +ve result for urine glucose w/ copper reduction tests but not w/ enzyme-based tests. False -ve ferricyanide test for glucose determination.

Cephalosporins

J01DD16 - cefditoren ; Belongs to the class of third-generation cephalosporins. Used in the systemic treatment of infections.

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