Severe hepatic impairment. Abrupt w/drawal may cause aggravation of symptoms. May cause excessive drop of BP. May affect ability to drive or operate machinery. Lactation. Childn.
Hypersensitivity. Elevation of liver enzymes, BUN, serum creatinine, total cholesterol, uric acid or triglycerides. Leucopenia, GI disturbances, dizziness, headache, facial hot flushes, feeling of warmth, conjunctival congestion, palpitation or tachycardia. Malaise, weakness, edema, pollakiuria.
Drug Interactions
May intensify action of other antihypertensive drugs, cimetidine.
C08CA11 - manidipine ; Belongs to the class of dihydropyridine derivative selective calcium-channel blockers with mainly vascular effects. Used in the treatment of cardiovascular diseases.
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