Epilepsy Adult Initially 25-50 mg at night for 1 wk, increased thereafter by increments of 25 or 50 mg at 1-2 wk intervals until effective dose is reached. Daily doses of >25 mg should be taken in 2 divided doses. Monotherapy: Usual dose range: 100-500 mg daily. Adjunctive therapy: Usual daily dose: 200-400 mg.
Childn ≥6 yr Monotherapy:
Initially 0.5-1 mg/kg at night for the 1st wk, increased thereafter by 0.5-1 mg/kg every 1 or 2 wk daily in 2 divided doses.
Childn ≥2 yr Adjunctive therapy: Initially 25 mg given as single dose at night for 1 wk, then increased by 1-3 mg/kg every 1 or 2 wk until effective dose is reached. Higher daily dose are divided & given bid. About 5-9 mg/kg is usually required.
Migraine Adult Initially 25 mg at night for 1 wk, increased by 25 mg increments every wk to usual dose of 50 mg bid.
Moderate to severe renal impairment (CrCl <70 mL/min/1.73 m2) ½ of usual adult dose.
Patient undergoing hemodialysis Supplemental dose equal to about ½ of daily dose given in divided doses (at start & finish of procedure).
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