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Incompatibilities: The IV compatibility and stability of methylprednisolone sodium succinate solutions and with other drugs in intravenous admixtures is dependent on admixture pH, concentration, time temperature, and the ability of methylprednisolone to solubilize itself. Thus, to avoid compatibility and stability problems, whenever possible it is recommended that methylprednisolone sodium succinate be administered separately from other drugs and as either IV push, through an IV medication chamber, or as an IV piggy-back solution.
Special precautions for disposal and other handling: Preparation for administration: Methylprednisolone sodium succinate is reconstituted with sterile water for injection or bacteriostatic water for injection containing 0.9% benzyl alcohol (500 mg/8 mL, 1g/16 mL vial and 2g/32 mL vial). For IV infusion, the reconstituted methylprednisolone sodium succinate should be further diluted with 5% dextrose, 0.9% sodium chloride, 5% dextrose in 0.9% sodium chloride injection.
Admixture compatibility: This solution may be added to indicated amounts of 5% dextrose in water, isotonic saline solution, or 5% dextrose in isotonic saline solution. Store reconstituted solution below 30°C. Use solution within 48 hours after mixing. Physical and chemical stability have been demonstrated for a period of 48 hours. However, from a microbiological point of view, the solution should be used immediately. If not used immediately, in-use storage times and conditions prior to use would normally not be longer than 24 hours at below 30°C since no antimicrobial preservative is included.
Parenteral methylprednisolone sodium succinate should be inspected visually for particulate matter and discoloration prior to and during administration whenever solution and container permit.
