Lineaz Drug Interactions

Metabolism/transport effects: Linezolid inhibits monoamine oxidase and may interact with drugs that are metabolized by monoamine oxidase. Avoid concomitant use of Linezolid with any of the following: alcohol (ethyl), apraclonidine, atomoxetine, atropine (ophthalmic), BCG (intravesical), bezafibrate, buprenorphine, bupropion, buspirone, carbamazepine, cyclobenzaprine, cyproheptadine, dapoxetine, deferiprone, dexmethylphenidate, dextromethorphan, diethylpropion, dipyrone, epinephrine (oral inhalation), fentanyl, hydromorphone, isometheptene, levonordefrin, MAO inhibitors, maprotiline, meperidine, mequitazine, methyldopa, methylene blue, methylphenidate, mianserin, mirtazapine, moclobemide, morphine (liposomal), morphine (systemic), nefazodone, nefopam, oxymorphone, pholcodine, pizotifen, reboxetine, selective serotonin reuptake inhibitors, serotonin 5-HT₁D receptor agonists, serotonin/norepinephrine reuptake inhibitors, tapentadol, tetrabenazine, tetrahydrozoline (nasal), tianeptine, trazodone, tricyclic antidepressant, tryptophan.
Importance of avoiding large quantities of foods or beverages with high tyramine content during Linezolid treatment; this includes foods or beverages that have been aged, fermented, pickled, or smoked to improve flavor (e.g., aged cheeses, fermented or air-dried meats, sauerkraut, soy sauce and other soybean condiments, tap beer, red wine). Consider that tyramine content of any protein-rich food may be increased if stored for long periods or improperly refrigerated.