Adults w/ partial onset seizures Initially 150 mg as total daily dose (as 75 mg bid or 50 mg tid). May increase dose to max of 600 mg/day.
Neuropathic pain Patients w/ CrCl of at least 60 mL/min Recommended dose: 150-300 mg/day (as 75-150 mg bid or 50-100 mg tid). Initially 75 mg bid or 50 mg tid, may be increased to 300 mg/day w/in 1 wk.
Patients who do not experience sufficient pain relief after 2-4 wk w/ 300 mg/day 300 mg bid or 200 mg tid (600 mg/day).
Neuropathic pain (diabetic neuropathy) Patients w/ CrCl of at least 60 mL/min Initially 50 mg tid, may be increased to max recommended dose of 300 mg/day (as 100 mg tid) w/in 1 wk.
Fibromyalgia Recommended dose: 300-450 mg/day. Initially 75 mg bid, may be increased to 150 mg bid w/in 1 wk.
Patients who do not experience sufficient benefit w/ 300 mg/day May further increase to 225 mg bid.
GAD 150-600 mg/day in 2-3 divided doses. Initially 150 mg/day, may be increased at wkly intervals in increments of 150-300 mg/day after 1 wk & up to 450 mg/day the following wk. Max: 600 mg/day after an additional wk. Total daily dose adjustment:
Patients w/ renal impairment CrCl ≥60 mL/min 150 mg bid or tid, 300 mg bid or tid, 450 mg bid or tid, 600 mg bid or tid,
30-60 mL/min 75 mg bid or tid, 150 mg bid or tid, 225 mg bid or tid, 300 mg bid or tid,
15-30 mL/min 25-50 mg once daily or bid, 75 mg once daily or bid, 100-150 mg once daily or bid, 150 mg once daily or bid,
<15 mL/min 25 mg once daily, 25-50 mg once daily, 50-75 mg once daily or 75 mg once daily. Supplementary single dose following hemodialysis:
Patients on 25 mg once daily regimen 1 supplemental dose of 25 mg or 50 mg,
25-50 mg once daily regimen 1 supplemental dose of 50 mg or 75 mg,
50-75 mg once daily regimen 1 supplemental dose of 75 mg or 100 mg,
75 mg once daily regimen 1 supplemental dose of 100 mg or 150 mg.
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