Lefloxin Special Precautions

Use only for treatment or prevention of infections proven or strongly suspected to be caused by susceptible bacteria. Moreover, culture and sensitivity test should be performed in order to determine the causative microorganism and to prevent further development of drug resistance.
LEFLOXIN should be administrated with caution in the following patients: Patients with impaired renal function; Patients with known or suspected CNS disorder that may predispose to seizure; Patients exposed to direct sunlight; Diabetic patients receiving concomitant treatment with an oral hypoglycemic agent or with insulin preparations; Patients with serious heart disease, e.g. arrhythmia and ischemic heart disease. QT prolonged may occur. Patients with uncorrected electrolytes imbalance (e.g. hypokalemia, hypomagnesemia) and patients receiving Class IA and III antiarrhythmic agents; Patients with myasthenia gravis, symptoms may be exacerbated.
Severe hepatotoxicity, including acute hepatitis, has occurred during taking this drug especially in geriatric patients. This drug should be discontinued in any patient who experiences loss of appetite, nausea, vomiting, fever, weakness, tiredness, right upper quadrant tenderness, itching, yellowing of the eyes and skin, light colored feces or dark colored urine.
Treatment with anti-infectives alters normal colon flora and may permit overgrowth of Clostridium difficile and fungi. C. difficile produces toxins which contribute to development of C. difficile associated diarrhea and colitis (CDAD).
Use in the Elderly: LEFLOXIN should be administrated with caution in geriatric patients.