Lefloxin Drug Interactions

1. Concomitant use of Levofloxacin and antacid, sucralfate, metal cations medications or multivitamins which compose of magnesium, aluminium, ferrous sulfate, zinc, calcium or iron may decrease the absorption of Levofloxacin. Levofloxacin should be administered at least 2 hours before or 2 hours after such the drugs. Although, there are no data concerning an interaction of intravenous quinolones with such the drugs, quinolones should not be co-administered with any solution containing such the drugs through the same intravenous line.
2. Concomitant use of Levofloxacin and theophylline, non-steroidal anti-inflammatory agents (e.g. fenbufen) possible increased risk of CNS stimulation which leads to seizures. Concomitant use of these drugs should be avoided.
3. Concomitant use of Levofloxacin and warfarin may result in increased prothrombin time. Patients receiving the drugs concomitantly should be monitored.
4. Concomitant use of Levofloxacin and antidiabetic agents may alter blood glucose concentrations and symptomatic hyperglycemia or hypoglycemia. Careful monitoring of blood glucose concentrations is recommended.
5. Concomitant use of Levofloxacin and antidepressant agents (e.g. fluoxetine, imipramine), antiarrhythmic agents may have additive effect on QT interval prolongation. Concomitant use of these drugs should be avoided.