Japrolox Contraindications

JAPROLOX TABLETS is contraindicated in the following patients: 1.Patients with peptic ulcers [peptic ulcers may be aggravated due to reduced gastric blood flow resulting from inhibition of prostaglandin biosynthesis]. (See Careful administration under Precautions.)
2. Patients with severe blood disorders [Platelet dysfunction may occur and the abnormality may be worsened].
3. Patients with severe hepatic function disorders [Liver damage has been reported as an adverse reaction, and the patient's liver dysfunction may be aggravated].
4. Patients with severe renal impairment [Adverse reactions such as acute kidney injury, nephritic syndrome, etc. may occur].
5. Patients with severe cardiac function failure [Cardiac symptoms may be exacerbated because inhibition of prostaglandin biosynthesis in the kidneys may cause edema and an increase in circulating body fluid volume, with a consequent increase in cardiac work].
6. Patients with a history of hypersensitivity to any ingredients of JAPROLOX.
7. Patients with a history of aspirin-induced asthma (induction of asthmatic attack with non-steroidal anti-inflammatory-analgesics, etc.) [May induce an aspirin-induced asthmatic attack].
8. Women in the late stages of pregnancy [See Use in Pregnancy & Lactation].