Adjunct to diet & exercise to improve glycemic control in type 2 DM as monotherapy or in combination w/ insulin (w/ or w/o metformin). For type 2 DM to improve glycemic control in combination w/ metformin as initial therapy, sulfonylurea, PPARγ agonist as initial therapy, metformin & sulfonylurea or metformin & PPARγ agonist (eg, thiazolidinediones) when diet & exercise plus the single agent do not provide adequate glycemic control.
Discontinue if hypersensitivity reaction including, anaphylaxis, angioedema & exfoliative skin conditions including SJS; pancreatitis; bullous pemphigoid is suspected. Not to be used in treating type 1 diabetes or diabetic ketoacidosis. Acute pancreatitis, including fatal & non-fatal hemorrhagic or necrotizing pancreatitis. Increased risk of severe joint pain. Hypoglycemia in combination w/ sulfonylurea or insulin. Not to be used concomitantly w/ alcohol. Not recommended during pregnancy. Not to be used during lactation. Childn <10 yr; <18 yr. Elderly w/ renal impairment.
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