Premed: Dexamethasone 20 mg orally 12 & 6 hr prior to therapy & cimetidine 300 mg IV or ranitidine 50 mg IV & diphenhydramine 50 mg IV 30 min prior to therapy.
Ovarian cancer & NSCLC Previously untreated patients Combination therapy: 175 mg/m
2 IV over 3 hr followed by platinum compd every 3 wk. Alternatively, 135 mg/m
2 over 24 hr followed by platinum compound every 3 wk.
2nd-line therapy for advanced metastatic ovarian carcinoma & metastatic disease or relapse w/in 6 mth of adjuvant chemotherapy Patients previously treated w/ chemotherapy Monotherapy: 175 mg/m
2 IV over 3 hr every 3 wk.
Breast cancer Adjuvant therapy: 175 mg/m
2 IV over 3 hr every 3 wk for 4 courses.
Kaposi's sarcoma 2nd-line therapy: 135 mg/m
2 IV over 3 hr w/ 3-wk interval between courses or 100 mg/m
2 IV over 3 hr w/ 2-wk interval between courses (dose intensity 45-50 mg/m
2/wk).
Sign Out
