Prevention of HBV re-infection after liver transplantation for hepatitis B induced liver failure. Immunoprophylaxis of hepatitis B in case of accidental exposure in non-immunised subjects (including persons whose vaccination is incomplete or status unknown); in haemodialysed patients; newborn of a HBV carrier-mother; in subjects who did not show an immune response after vaccination & for whom a continuous prevention is necessary due to the continuous risk of being infected w/ hepatitis B.
IMPrevention of HBV re-infection after liver transplantation for hepatitis B-induced liver failure Adult2,000 IU every 15 days. Immunoprophylaxis of hepatitis B:Prevention in accidental exposure in non-immunised subjects500 IU w/in 24-72 hr. Immunoprophylaxis inhaemodialysed patients8-12 IU/kg w/ a max of 500 IU every 2 mth until seroconversion following vaccination. Prevention in newborns of a hepatitis B virus carrier-mother 30-100 IU/kg at birth or as soon as possible. May be repeated until seroconversion following vaccination. Subjects w/ no known response after vaccination or require continuous prevention Adult 500 IU. Childn 8 IU/kg every 2 mth to achieve at least 10 mIU/mL.
Do not administer into blood vessel. Patients who are HBsAg-carrier, IgA-deficient, or on controlled Na diet. Discontinue if allergic or anaphylactic type reactions occur. May interfere w/ some serological tests for red cell antibodies eg, Coombs' test. Pregnancy & lactation.
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