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Imcitin

Imcitin

imipenem + cilastatin

Manufacturer:

M & H Manufacturing

Distributor:

B L H Trading

Marketer:

M & H Manufacturing
Concise Prescribing Info
Contents
Imipenem 500 mg, cilastatin 500 mg
Indications/Uses
Infections of resp tract, intra-abdominal, gynecological, bone & joint, skin & skin structure, GUT; septicemia; infective endocarditis.
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Dosage/Direction for Use
IV infusion Adult (CrCl >70 mL/min/1.73 m2 & weighing ≥70 kg) Max total daily dose: 50 mg/kg or 4 g daily. Severe infection Fully-susceptible: 500 mg every 6 hr. Total daily dose: 2 g.  Moderately-susceptible: 1,000 mg every 6-8 hr. Total daily dose: 3-4 g. Moderate infection Fully-susceptible: 500 mg every 6-8 hr. Total daily dose 1.5-2 g. Moderately-susceptible: 500 mg every 6 hr. Total daily dose: 1.5 g. Alternatively, 1,000 mg every 8 hr. Total daily dose: 3 g. Mild infection Fully-susceptible: 250 mg every 6 hr. Total daily dose: 1 g. Moderately-susceptible: 500 mg every 6 hr. Total daily dose: 2 g. Renal impairment CrCl 30-70 mL/min/1.73 m2 500 mg every 8 hr, 20-30 mL/min/1.73 m2 500 mg every 6 hr, 5-20 mL/min/1.73 m2 250 mg every 8 hr. Childn >3 mth 15-25 mg/kg every 6 hr. Susceptible infections 2 g/day. Moderately susceptible infections 4 g/day. Cystic fibrosis 90 mg/kg/day in divided doses. Max: 4 g/day. Neonates 4 wk to 3 mth 25 mg/kg every 6 hr, 1-4 wk 25 mg/kg every 8 hr, <1 wk 25 mg/kg every 12 hr.
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Overdosage
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Contraindications
Hypersensitivity.
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Special Precautions
Discontinue if allergic reaction occurs. Avoid concomitant use w/ valproic acid & divalproex Na. History of GI disease particularly colitis; CNS disorders (eg, brain lesions or history of seizures) &/or compromised renal functions. Continue anticonvulsant therapy w/ a known seizure disorder. Do not use in patients w/ CrCl ≤5 mL/min/1.73 m2 unless hemodialysis is instituted w/in 48 hr. Patients on hemodialysis. Pregnancy & lactation. Childn <3 mth & w/ impaired renal function.
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Adverse Reactions
Nausea, diarrhea, vomiting, staining of teeth &/or tongue, pseudomembranous colitis; eosinophilia, leukopenia, neutropenia including agranulocytosis, thrombocytopenia, thrombocytosis & decreased Hb, pancytopenia & prolonged PT; myoclonic activity, psychic disturbances including hallucinations, confusional states or seizures, paresthesia, encephalopathy; rash, pruritus, urticaria, erythema multiforme, SJS, angioedema, candidiasis, fever including drug fever, anaphylactic reactions; oliguria/anuria, polyuria, serum creatinine & BUN elevations, urine discoloration, erythema, local pain & induration, phlebitis &/or thrombophlebitis, increases in serum transaminases, bilirubin &/or serum alkaline phosphatase; hypotension.
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Drug Interactions
Generalized seizures w/ ganciclovir. Reduce conc of valproic acid.
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Storage
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Description
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Action
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MIMS Class
Other Beta-Lactams
ATC Classification
J01DH51 - imipenem and cilastatin ; Belongs to the class of carbapenems. Used in the systemic treatment of infections.
Presentation/Packing
Form
Imcitin powd for inj
Packing/Price
1's
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