Initial dose:
Anemia in chronic renal failure patients Adult 50-100 IU/kg 3x a wk IV or SC.
Childn weighing >30 kg 30-100 IU/kg 3x wkly,
10-30 kg 60-150 IU/kg 3x wkly,
<10 kg 75-150 IU/kg 3x wkly. Initial dose is same as adult dose.
Anemia in HIV-infected patients (zidovudine-induced) 100 IU/kg 3x wkly IV or SC
for 8 wk.
Anemia in cancer patients on chemotherapy Adult 150 IU/kg/dose 3x a wk SC,
may be increased by 50 U/kg/dose each time. Max: 300 U/kg 3x wkly or initially 40,000 IU SC once wkly. TIW administration: If Hb level reaches 12 g/dL or increases >1 g/dL w/in 2 wk, reduce dose by 25%. If hematocrit is 40%, interrupt therapy until value reaches 36%. Reduce dose by 25% when treatment is re-initiated. Single wkly administration: Increase to 60,000 IU if Hb did not increase 1 g/dL in 4 wk. If Hemax triggers rapid response, reduce dose by 25%.
Childn 6 mth to 18 yr 25-300 IU/kg IV or SC 3-7x wkly.
Reduction of allogeneic blood transfusion in surgery patients 150-300 IU/kg/day SC starting 10 days before surgery & continuing up to 4 days after. Alternatively, 600 IU/kg. SC unique wkly doses on days 21, 14, & 7 prior to surgery & 4th dose on surgery day.
Anemia of prematurity 250 IU/kg 3x a wk SC.
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