Systemic fungal infections eg, blastomycosis, chromomycosis, coccidioidomycosis, paracoccidioidomycosis; in patients who have failed or intolerant to other therapies.
Min duration of treatment: Candidiasis 1-2 wk, recalcitrant dermatophyte infections 4 wk, systemic mycoses 6 mth. Adult Initially 200 mg once daily. May be increased to 400 mg once daily. Childn ≥2 yr 3.3-6.6 mg/kg daily.
Patients requiring prolonged therapy or w/ history of liver disease. Measure LFTs eg, alkaline phosphatase, ALT, AST & bilirubin before starting & during treatment. Concomitant use w/ hepatotoxic drugs; antacids, anticholinergics & H2-blockers. May impair ability to drive & use machines. Hepatic impairment. Pregnancy. Should not breastfeed while on treatment. Childn <2 yr.
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