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Pharmacology: Macrogols of high molecular weight are long linear polymers which retain water molecules by means of hydrogen bonds. Administered by oral route, they give rise to an increase in the volume of intestinal liquids. The volume of unabsorbed intestinal liquid accounts for the laxative properties of the solution.
Pharmacokinetics: The pharmacokinetic data confirms that Macrogol 4000 undergoes neither gastrointestinal resorption nor biotransformation following oral ingestion.
