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Pharmacology: Pharmacodynamics: Azithromycin binds to the 23S rRNA of the 50s ribosomal subunit of susceptible microorganisms, thus, interfering with microbial protein synthesis.
Pharmacokinetics: Absorption: Oral: Rapid from the GI tract.
Distribution: Extensive tissue, distributes well into skin, lungs, sputum, tonsils, and cervix; penetration into CSF is poor; Vd: 31 to 33 L/kg.
Protein binding: 7% to 51%.
Metabolism: Hepatic to inactive metabolites.
Bioavailability: 34% to 52%.
Half-life elimination: Adults: 68 to 72 hours.
Time to peak: 2 to 3 hours.
Excretion: Biliary (major route 50%, unchanged) urine (6% to 14% unchanged).
