Floctil Drug Interactions

Azithromycin is metabolized by enzyme CYP3A4 (minor).
Azithromycin inhibits enzyme CYP1A2 (weak), P-glycoprotein.
Concurrent use of ergot derivative and macrolide antibiotics may result in an increased risk of acute ergotism (nausea, vomiting, vasospastic ischemia).
Concurrent use of azithromycin and warfarin may result in an increased risk of bleeding.
Concurrent use of azithromycin and digoxin may result in digoxin toxicity (vomiting, cardiac arrhythmias).
Concurrent use of azithromycin and simvastatin, lovastatin, or atorvastatin may result in an increased risk of rhabdomyolysis.
Concurrent use of azithromycin and imipramine, lopinavir, apomorphine, nilotinib, vardenafil, citalopram, paliperidone, alfuzosin, lumefantrine, trazodone, granisetron, ranolazine, solifenacin, sunitinib, promethazine, mifepristone, arsenic trioxide, salmeterol, nortriptyline, norfloxacin, clozapine, sorafenib, chloroquine, propafenone, haloperidol, posaconazole, ciprofloxacin, gemifloxacin, ondansetron, pentamidine, ofloxacin, amitriptyline, voriconazole, clomipramine, fluconazole, ketoconazole, quinine, lapatinib, trimipramine, flecainide, octreotide, prochlorperazine, chlorpromazine, pazopanib, mefloquine, domperidone, sodium phosphate may result in an increased risk of QT interval prolongation.
Concurrent use of azithromycin and procainamide may result in an increased risk of QT interval prolongation and serious cardiac events.
Concurrent use of azithromycin and Class III antiarrhythmic agents may result in an increased risk of cardiotoxicity.
Concurrent use of azithromycin and theophylline may result in increase serum theophylline may result in increased serum theophylline.
Concurrent use of azithromycin and phenytoin may result in increased serum phenytoin levels.
Concurrent use of azithromycin and cyclosporine may result in increased serum cyclosporine levels.
Concurrent use of azithromycin and aluminium- or magnesium-containing products may result in decreased azithromycin plasma concentration.
Concurrent use of azithromycin and carbamazepine may result in increased serum carbamazepine levels.