Essential HTN, heart failure & impaired left ventricle systolic function (LVEF ≤40%), as add-on therapy to ACE inhibitors or when ACE inhibitors are not tolerated.
HTN 8-32 mg once daily. Heart failure Initially 4 mg once daily, up-titration to the highest target dose 32 mg or tolerated dose by doubling the dose intervals of at least 2 wk.
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