Fercirol Mechanism of Action

Pharmacology: Pharmacodynamics: FERCIROL contain Iron (III) hydroxide polymaltose complex, which is absorbed into reticulo-endothelial system cells where it is ionized to Fe³⁺, transported to the bone marrow via transferrin, and incorporated into hemoglobin. A minor amount of Fe³⁺ is stored as hemosiderin and ferritin or incorporated into myoglobin or heme-containing enzymes.
Folic acid, which is an exogenous source of folate is required for nucleoprotein synthesis and the maintenance of normal erythropoiesis. Folic acid is not metabolically active as such, but is the precursor of tetrahydrofolic acid which is involved as a cofactor for 1-carbon transfer reactions in the biosynthesis of purines and thymidylates of nucleic acids. Impairment of thymidylate synthesis in patients with folic acid deficiency is thought to account for the defective DNA synthesis that leads to megaloblast formation and megaloblastic and macrocytic anemias. Folate is involved in amino acid interconversions (e.g., catabolism of histidine to glutamic acid, interconversion of serine and glycine, conversion of homocysteine to methionine), and generation of formate.
Pharmacokinetics: Iron (III) hydroxide polymaltose complex: Iron (III) hydroxide polymaltose complex has rapid absorption. Following absorption, it is minimally excreted in feces, skin and gastrointestinal epithelial cell exfoliation, perspiration, bile, urine. Women experience iron loss during menstruation. 
Folic acid: Folic acid is absorbed rapidly from the GI tract. Following oral administration, peak folate activity in blood occurs within 30-60 minutes. Synthetic folic acid is almost 100% bioavailable when administered in fasting individuals, bioavailability of synthetic folic acid consumed with a meal ranges from 85-100%. Tetrahydrofolic acid and its derivatives are distributed into all body tissues. Folic acid is distributed into milk. Following absorption of 1 mg or less, folic acid is largely reduced and methylated in the liver to N⁵-methyltetrahydrofolic acid, which is the main transport form of folate in the body. The excess folate is excreted unchanged in urine after maximum renal tubular reabsorption.