Major depressive disorder, generalized anxiety disorder, obsessive-compulsive disorder, & panic disorder AdultInitially 10 mg once daily, may be increased to 20 mg once daily at least 1 wk, >18 yr Initially 10 mg once daily, may be increased to 20 mg once daily after at least 3 wk.Elderly10 mg once daily.
Severe renal impairment. Closely monitor patients for clinical worsening, suicidality, or unusual changes in behavior during initial 1-2 mth of therapy. Discontinue if worsening of depression & symptoms occurs. History of seizure disorder or condition predisposing to seizures. Hyponatremia (increased in elderly). Exacerbation of sexual dysfunction. Concomitant use w/ CNS depressants, aspirin, NSAIDs, warfarin or anticoagulants. Patients w/ known bleeding tendencies. Pregnancy & lactation. Childn 12 yr (not FDA approved).
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