Permanently discontinue in patients who develop seizure during treatment. Consider discontinuation for Grade 3 & 4 cerebrovascular & ischemic CV events. Monitor for signs & symptoms of ischemic heart disease & cerebrovascular disorders. Optimize management of CV risk factors eg, HTN, diabetes or dyslipidemia. Monitor & manage patients at risk for fractures. Evaluate patients for risk of fracture; fall. May impair fertility in males of reproductive potential. Male patients w/ female partners of reproductive potential should use effective contraception during treatment & for 3 mth after last dose. Pregnancy & lactation. Ped patients. Increased frequency of falls in elderly.
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