May be taken with or without food: Take w/o any break, preferably at the same time each day w/ some liqd.
Contraindications
Hypersensitivity. Active venous thromboembolic disorder, past or present arterial & CV disease (eg, MI, CVA, ischemic heart disease), DM w/ vascular involvement, known or suspected sex hormone-dependent malignancies, undiagnosed vag bleeding. Presence or history of severe hepatic disease & benign or malignant liver tumours.
May aggravate uterine bleeding in women w/ adenomyosis uteri or uterine leiomyomata. Discontinue in anemia; long-term immobilization; symptoms of arterial or venous thrombotic event or suspicion; when depression, cholestatic jaundice &/or pruritus recur. Changes in menstrual bleeding pattern; persistent ovarian follicles. May slightly increase risk of stroke in women w/ HTN; venous thromboembolism (DVT, pulmonary embolism), breast cancer. Increased risk of thromboembolism in the puerperium. Consider hepatic tumour in the differential diagnosis when severe abdominal pain, liver enlargement or signs of intra-abdominal hemorrhage occur. History of depression; diabetic women, especially those w/ history of gestational DM; history of extrauterine pregnancy or tube function impairment. Decrease in bone mineral density (BMD) in lumbar spine. Perform risk-benefit assessment in patients at increased risk of osteoporosis before starting treatment. Adequate intake of Ca & vit D. W/draw treatment in sustained HTN. Avoid exposure to sun or UV radiation during therapy in women w/ tendency to chloasma. Galactose intolerance, total lactase deficiency or glucose-galactose malabsorption. Contraindicated in present or past severe hepatic disease. Pregnancy & lactation. Childn prior to menarche.
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