Edarbyclor Description

Each film-coated tablet contains azilsartan medoxomil 40 mg and chlorthalidone 12.5 or 25 mg.
Edarbyclor is a combination of azilsartan medoxomil (ARB; as its potassium salt) and chlorthalidone (thiazide-like diuretic).
Azilsartan medoxomil, a prodrug, is hydrolyzed to azilsartan in the gastrointestinal tract during absorption. Azilsartan is a selective AT₁ subtype angiotensin II receptor antagonist. Chlorthalidone is a monosulfamyl thiazide-like diuretic that differs chemically from thiazide diuretics by the lack of a benzothiadiazine structure.
The potassium salt of azilsartan medoxomil, azilsartan kamedoxomil, is chemically described as (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate monopotassium salt. Its empirical formula is C₃₀H₂₃KN₄O₈.
Chlorthalidone is chemically described as 2-chloro-5(1-hydroxy-3-oxo-1-isoindolinyl) benzenesulfonamide. Its empirical formula is C₁₄H₁₁ClN₂O₄S.