Increased CV & thrombotic adverse events in prolonged use. Patients w/ CV disease, using concomitant aspirin, corticosteroids, SSRIs or other NSAIDs, alcohol intake, or w/ history of, or active, GI disease eg, ulceration, bleeding, or inflammatory conditions & elderly may develop GI complications in concomitant use w/ NSAIDs. W/ or w/o known history of sulfonamide allergy. Discontinue at the 1st appearance of skin rash, mucosal lesions or any other sign of hypersensitivity. Severe hypotension may occur. Concomitant use w/ oral anticoagulants. HTN. Monitor BP closely during initiation of & throughout course of therapy. Compromised cardiac function, preexisting edema or other conditions pre-disposing to or worsened by fluid retention including patients taking diuretics or at risk of hypovolemia. Closely monitor renal function in patients w/ advanced renal disease. Rehydrate patients prior to & at initiation of therapy. Moderate & severe hepatic impairment. Pregnancy & lactation.
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