Perform digital rectal exam & other evaluations for prostate cancer risk including PSA testing prior to initiation of therapy & periodically thereafter. Establish new prostate-specific antigen (PSA) baseline after 6 mth of treatment. Risk of prostate cancer, orthostatic hypotension, intraoperative floppy iris syndrome. Consider to discontinue use for 1-2 wk prior to cataract surgery. Possible occurence of breast cancer in men. Concomitant use w/ α-adrenergic blockers & phosphodiesterase-5 inhibitors; strong CYP3A4 eg, ketoconazole & CYP2D6 inhibitors eg, paroxetine; moderate CYP3A4 inhibitors eg, erythromycin in combination w/ either strong or moderate CYP2D6 inhibitors; patients known to be poor CYP2D6 metabolisers. Liver disease. May impair ability to drive or operate machinery.
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