Not to be inj sub-conjunctively; introduced directly into the anterior eye chamber. Discontinue treatment if infection develops; at 1st sign of tendon inflammation. Overgrowth of non-susceptible organisms, including fungi in prolonged use. Ocular HTN/glaucoma. Increased risk of corticosteroid-induced increased IOP in diabetic patients. Perforations. Secondary ocular infections (bacterial, viral, or fungal) in prolonged use (w/in 2 wk). May promote, aggravate or mask signs & symptoms of eye infections caused by opportunistic microorganisms. Patients w/ dry eyes & compromised cornea. Examine patient w/ aid of magnification eg, slit-lamp biomicroscopy, or fluorescein staining. Frequently check IOP. Refer to ophthalmologist for evaluation of possible causes of blurred vision or other visual disturbances, which may be related to cataract surgery complications, development of glaucoma or rare diseases eg, central serous chorioretinopathy. Monitor patients in case of prolonged use. Not to wear contact lenses during therapy after cataract surgery. May slow corneal wound healing w/ topical ocular NSAIDs & steroids. May affect ability to drive or use machines. Renal & hepatic impairment. Increased risk of intra-uterine growth retardation, lower birth wt & risk for high BP, vascular disorders & insulin resistance in adulthood in prolonged or repeated corticosteroid use during pregnancy. Observe for signs of hypoadrenalism in infants born of mothers who have received corticosteroids during pregnancy. Not recommended during pregnancy especially during 1st 3 mth. Lactation. Not recommended in childn & adolescents <18 yr. Tendon inflammation & rupture in older patients. Levofloxacin: Discontinue treatment if allergic reaction occurs. Dexamethasone: Progressively discontinue treatment if Cushing's syndrome &/or adrenal suppression after intensive or long-term continuous therapy in predisposed patients including childn & patients treated w/ CYP3A4 inhibitors including ritonavir & cobicistat.
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