Complicated intra-abdominal infections caused by E. coli, Klebsiella pneumoniae, P. aeruginosa, Bacteroides cascae, B. fragilis, B. thetaiotaomicron, B. uniformis, B. vulgatus, Strep intermidius, S. constellatus & Peptostreptococcus micros. Complicated UTI, including pyelonephritis caused by E. coli including cases w/ concurrent bacteremia, K. pneumoniae, Proteus mirabilis, P. aeruginosa & Acinetobacter baumannii. Nosocomial pneumonia including ventilator-associated pneumonia (VAP).
IV infusionComplicated intra-abdominal infections 500 mg every 8 hr for 1 hr infusion time for 5-14 days. Complicated UTIs, including pyelonephritis 500 mg every 8 hr for 1 hr infusion time for 10 days. May be extended up to 14 days in patients w/ concurrent bacteremia. Nosocomial pneumonia, including VAP 500 mg every 8 hr for 1-4 hr infusion time for 7-14 days. Renal function impairment ≥30 to ≤50 mL/min 250 mg IV over 1 hr every 8 hr, >10 to <30 mL/min 250 mg IV over 1 hr every 12 hr.
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