AML 20 mg/m
2 BSA IV infusion over 1 hr repeated daily for 5 consecutive days (total: 5 doses per treatment cycle). Total daily dose: Not to exceed 20 mg/m
2; total dose per treatment cycle: Not to exceed 100 mg/m
2. Repeat cycle every 4 wk depending on patient's clinical response & observed toxicity.
MDS 3-day dosing treatment regimen: 15 mg/m
2 over 3-hr period every 8 hr for 3 consecutive days (total: 9 doses per treatment cycle). May be repeated approx every 6 wk. Total daily dose: Not to exceed 45 mg/m
2; total dose per treatment cycle: Not to exceed 135 mg/m
2. 5-day dosing treatment regimen: 20 mg/m
2 over 1 hr repeated daily for 5 consecutive days (total: 5 doses per treatment cycle). Total daily dose: Not to exceed 20 mg/m
2; total dose per treatment cycle: 100 mg/m
2. Repeat cycle every 4 wk depending on patient's clinical response & observed toxicity.
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