Clinoril Use In Pregnancy & Lactation

Use in Pregnancy: CLINORIL should be used during the first two trimesters of pregnancy only if the potential benefit justifies the potential risk to the fetus. Use of CLINORIL during the third trimester of pregnancy is not recommended.
The known effects of drug of this class on the human fetus during the third trimester of pregnancy include: Constriction of the ductus arteriosus prenatally, tricuspid incompetence, and pulmonary hypertension; non-closure of the ductus arteriosus postnatally which may be resistant to medical management; myocardial degenerative changes, platelet dysfunction with resultant bleeding, intracranial bleeding, renal dysfunction or failure, renal injury/dysgenesis which may result in prolonged or permanent renal failure, oligohydramnios, gastrointestinal bleeding or perforation and increased risk of necrotizing enterocolitis.
Use in Lactation: It is not known whether sulindac is excreted in human milk. Because other drugs of this class are excreted in human milk, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.