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Clinoril (Sulindac) is a nonsteroidal, antirheumatic agent with anti-inflammatory, analgesic and antipyretic properties.
CLINORIL is a prodrug. Following absorption, sulindac undergoes two major biotransformations: Reversible reduction to the sulfide metabolite and irreversible oxidation to the inactive sulfone metabolite. The sulfide metabolite is a potent inhibitor of prostaglandin synthesis.
CLINORIL usually provides prompt symptomatic relief of inflammation, pain and tenderness, and promotes early restoration of joint mobility. The drug has a prolonged duration of activity, which permits a once- or twice-a-day dosage schedule and may be used for long-term treatment.
Because CLINORIL is excreted in the urine primarily as biologically inactive forms, it may affect renal function less than other non-steroidal anti-inflammatory drugs; however, renal side effects have been reported infrequently with CLINORIL.
