In combination w/ ciclosporin (for microemulsion) & corticosteroids for the prophylaxis of organ rejection in adults at low to moderate immunological risk receiving an allogeneic renal or cardiac transplant. In combination w/ tacrolimus & corticosteroids for the prophylaxis of organ rejection in patients receiving a hepatic transplant.
Adult Initially 0.75 mg bid administered as soon as possible after general kidney & heart transplantation & 1 mg bid approx 4 wk after hepatic transplantation. Adjust dose at 4- to 5-day intervals based on achieved blood levels, tolerability, response, change in co-medications & clinical situation. Recommended everolimus whole blood trough levels: 3-8 ng/mL.
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