IM/IV Inj deep IM into large muscle mass. Inj direct IV over 3-5 min or as intermittent infusion over 30-60 min.
Adult & geriatric Mild infections caused by susceptible gm +ve cocci 250-500 mg every 8 hr.
Moderate to severe infections 500 mg to 1 g every 6-8 hr.
Severe, life-threatening infections (eg, endocarditis, septicemia) 1-1.5 g every 6 hr. May use up to 12 g daily in rare instances.
Pneumococcal pneumonia 500 mg every 12 hr.
Uncomplicated UTI 1 g every 12 hr.
Group B Strep (perinatal prophylaxis) 2 g IV at the time of onset of labor or rupture of membranes followed by 1 g IV every 8 hr until delivery.
Perioperative prophylaxis 1-2 g administer 30 min to 1 hr prior to start of surgery. Procedures ≥2 hr: 500 mg to 1 g during surgery; 24 hr post-op: 500 mg to 1 g every 6-8 hr. In surgery where infection may be particularly devastating (eg, open-heart, prosthetic arthroplasty): May continue prophylactic administration for 3-5 days following the completion of surgery.
Childn >1 mth 25-50 mg/kg daily divided in 3 or 4 doses.
Severe infections May be increased to 100 mg/kg daily divided in 3 or 4 doses. Max: 6 g daily.
Renal impairment: Adult w/ CrCl 35-54 mL/min Administer full dose in ≥8-hr interval,
11-34 mL/min Administer 50% of usual dose every 12 hr,
≤10 mL/min Administer 50% of usual dose every 18-24 hr.
Ped w/ CrCl >70 mL/min No dosage adjustment necessary,
40-70 mL/min 60% of usual daily dose divided every 12 hr,
20-40 mL/min 25% of usual daily dose divided every 12 hr,
5-20 mL/min 10% of usual daily dose divided every 24 hr.
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