Adult Cryptococcal meningitis & infections at other sites, candidemia, disseminated candidiasis & other invasive candidal infections 400 mg on 1st day followed by 200 mg once daily. May be increased to 400 mg daily. Treatment duration: 6-8 wk for cryptococcal meningitis.
Prevention of relapse of cryptococcal meningitis in patients w/ AIDS 200 mg daily following full course of primary therapy.
Oropharyngeal candidiasis 50 mg once daily for 7-14 days.
Atrophic oral candidiasis associated w/ dentures 50 mg once daily for 14 days.
Other mucosal candida infections (except vag candidiasis) 50 mg daily for 14-30 days. May be increased to 100 mg daily in unusually difficult cases.
Vag candidiasis 150 mg as single dose.
Tinea pedis, tinea corporis, tinea cruris & candida infections 150 mg once wkly or 50 mg once daily for 2-4 wk (up to 6 wk for Tinea pedis).
Tinea versicolor 50 mg once daily for 2-4 wk.
Tinea unguium 150-450 mg once wkly for 3-12 mth.
Prevention of fungal infection in patients w/ malignancy 50 mg once daily.
Prevention of candidiasis 50-400 mg once daily.
Patient at high risk of systemic infection 400 mg once daily. Start treatment several days before anticipated onset of neutropenia & continue for 7 days after neutrophil count rise >1,000 cells/mm
3.
Childn >1 yr w/ normal renal function Superficial candidal infections 1-2 mg/kg daily.
Systemic candidal/cryptococcal infections 3-6 mg/kg daily.
Childn ≤4 wk 1-2 mg/kg administered every 72 hr then decrease to once daily after 2 wk.
Renal impairment CrCl >40 mL/min Normal daily dose every 24 hr,
21-40 mL/min ½ of normal daily dose or normal dose every 48 hr,
10-20 mL/min 1/
3 of normal daily dose or normal dose every 72 hr.
Patient on regular dialysis 1 dose after every dialysis session.
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