DVT, pulmonary embolism, heart attack, stroke, immobilization, 4 wk prior to surgery, diabetes, high BP, protein C deficiency, hepatic inflammation, jaundice, raised bilirubin levels, liver tumor, severe stomachache, porphyria, hormone-dependent malignant tumor, severe disorders of fat metabolism, pancreatitis associated w/ increased triglycerides, migraine, headache, migraine accompagnee, sudden perception & movement disorders, worsened epileptic fits, severe depression, otosclerosis, amenorrhea, endometrial hyperplasia, vag bleeding of unknown origin, risks of blood clotting disorders. Pregnancy & lactation.